844-SOS-PETS (767-7387)


Overview of the Canine Immune System

After practicing as an Animal Naturopath for many years and analyzing the feedback from my studies, I believe the root cause of most diseases is a compromised immune system.

I believe many dogs may not achieve optimal health due to a lack of knowledge and misinformation about how to keep our beloved pets healthy and protected from illness.

The allopathic approach is to look at the symptoms and find ways to address those with medication. This often results in the use of more than one medication. This is not the approach of an animal naturopath, which focuses on the root cause.

As an animal naturopath, I first look at the diet. Is it appropriate to a dog’s digestive system? Dogs and cats are members of the carnivore family, and their preferred diet consists of raw meats and bones. I know some do not agree with that, but an increasing number of pet owners do. From my 20-some years of experience with feeding a raw food diet to my dogs and cats, plus consulting in more than 400 cancer cases, there is no way around not feeding a raw food diet. You cannot restore the immune system on any other diet. This is becoming more and more clear to me and many others. 

In order to understand this we need to understand a dog’s and cat’s immune system.

The immune system in dogs is a complex network of cells, tissues, and organs that work together to defend the body against harmful invaders. It consists of two main components:

1. The innate immune system
2. The adaptive immune system

The Innate Immune System

The innate immune system is a dog’s first line of defense. It provides immediate, non-specific protection against foreign invaders. When the immune system is solid and functional, most harmful pathogens are killed, and you will never know your animal was exposed to them. 

Here are some key points about the innate immune system:

  • It acts as the “bouncer” of the dog’s body, working to keep foreign molecules out.
  • This system doesn’t change its reaction to invaders after multiple exposures.

Key components of the innate immune system include:

  • Mucous (capsulate the pathogens)
  • Skin 
  • Chemicals in saliva
  • Stomach acids

The Adaptive Immune System

The adaptive immune system is more sophisticated and provides a targeted response to specific threats. Here’s how it works:

  • It serves as a backup team if an invader gets past the innate system.
  • This system changes its tactical methods based on the type of substance invading the dog’s body.
  • The adaptive system has the ability to:
  • Communicate between its agents
  • Retain memory of foreign substances
  • Modify its combat methods based on previous encounters

Cooperation Between Systems

It’s important to note that the innate and adaptive immune systems don’t work in isolation. They collaborate to provide comprehensive protection:

  • The innate system is the first line of defense, aiming to stop invaders before they cause illness.
  • If an invader bypasses the innate system, the adaptive system steps in to help the dog recover from the resulting illness.


The immune system in dogs is a sophisticated network that combines immediate, non-specific defenses with targeted, adaptive responses. This dual approach allows dogs to combat a wide range of potential threats to their health effectively.

Let’s dig a little deeper…

This part delves into the components, functions, and ways to support the canine immune system.

One thing I have observed over the last 25 years as an animal naturopath who has helped hundreds of pet owners is that the more people know about their pets, the better decisions they make regarding food and nutrition. The most important one is the immune system. A healthy immune system can drastically extend the life of a dog or cat and protect them from most diseases. 

Components of the Canine Immune System

The immune system in dogs consists of various cells, organs, and substances that work together to defend the body against foreign invaders.

Key Components

  1. White Blood Cells (Leukocytes): These are the frontline soldiers of the immune system responsible for identifying and attacking pathogens.
  2. Antibodies: Specialized proteins produced by B lymphocytes that target specific antigen
  3. T Cells: A type of white blood cell that plays a central role in coordinating immune responses.
  4. Bone Marrow: The site where new blood cells, including white blood cells, are produced.
  5. Thymus Gland: An organ where T cells mature and multiply.
  6. Spleen: Acts as a filter for blood, removing old or damaged blood cells and capturing pathogen.
  7. Lymph Nodes**: Trap microorganisms and foreign substances, providing a place for immune cells to interact and generate a response.

![Activation of T and B cells](https://upload.wikimedia.org/wikipedia/commons/thumb/5/55/Activation_of_T_and_B_cells.png/500px-Activation_of_T_and_B_cells.png)

### Immune System Functions

1. **Physical Barriers**: The first line of defense includes the skin and mucous membranes that prevent pathogens from entering the body.
2. **Innate Immunity**: Present at birth, this nonspecific defense mechanism responds to pathogens in a generic way.
3. **Adaptive Immunity**: Acquired over time, this specific immunity targets particular pathogens that the body has previously encountered.

## Immune System Health and Support

### Nutrition and Supplements

1. **Proteins**: Essential for the production of immune cells and antibodies.
2. **Omega-3 Fatty Acids**: Promote immune health and have anti-inflammatory properties.
3. **Antioxidants**: Vitamins A, C, E, and B-Carotene help protect against free radical damage.
4. **Probiotics and Prebiotics**: Enhance gut health, which is crucial as nearly 70% of the immune system is located in the gut.

### Lifestyle Factors

1. **Regular Exercise**: Helps maintain a healthy immune system by reducing fat and inflammation.
2. **Stress Management**: Chronic stress can weaken the immune system, so it’s important to minimize stress in dogs.
3. **Vaccinations**: Essential for protecting dogs from serious diseases like rabies and distemper.

![Neutrophil with anthrax](https://upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Neutrophil_with_anthrax_copy.jpg/500px-Neutrophil_with_anthrax_copy.jpg)

## Immune-Mediated Diseases

While a strong immune system is crucial for health, an overactive immune system can lead to autoimmune diseases where the body attacks its own cells.

1. **Autoimmune Diseases**: Conditions like canine lupus, Addison’s disease, and rheumatoid arthritis are caused by an overactive immune system.
2. **Treatment**: Often involves immunosuppressive drugs to reduce the inappropriate immune response.

## Conclusion

Understanding the canine immune system is essential for ensuring the health and well-being of dogs. By providing proper nutrition, regular exercise, and minimizing stress, dog owners can support their pets’ immune systems effectively. Regular veterinary check-ups and vaccinations are also crucial in maintaining a robust immune defense.

By following these guidelines, dog owners can help their pets lead healthier, happier lives, free from the burden of frequent illnesses and infections.

join long living pets research projects

This is the World’s Longest and Largest Observational Study into raw fed dogs and cats. Thousands of dogs and cats are participating. We will follow these dogs for their entire life and report and document their lifespan and health.

If you feed a raw food diet you are welcome to participate in the study.

More here

Long Living Pets Rescue and Rehab CenterLong Living Pets Rescue and Rehab Center adopt pets that are scheduled for euthanasia and heal them holistically.

If you want to learn more and help share this project with others…

More here